B1265
Title: Optimal designs for the detection and characterisation of hormesis in toxicological tests
Authors: Sergio Pozuelo Campos - University of Castilla-La Mancha (Spain) [presenting]
Victor Casero-Alonso - University of Castilla-La Mancha (Spain)
Mariano Amo-Salas - University of Castilla-La Mancha (Spain)
Abstract: Toxicological tests are experiments that allow the effect of a toxicant on organisms, ecosystems, etc., to be determined. The focus is on tests in the aquatic environment, in which the Ceriodaphnia Dubia test has a particular interest. It has been found that hormesis occurs in two out of three of the experiments carried out with this organism. We apply the theory of optimal design of experiments to a linear quadratic model with Poisson distribution to obtain designs that allow us to detect and characterise hormesis efficiently. For this purpose, different utility functions, such as the dose at which the maximum concentration is reached, the AUC, the ZEP, the RIp or the RIMp are used.
