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B0918
Title: Sparse semiparametric canonical correlation analysis for data of mixed types Authors:  Grace Yoon - Texas A and M University (United States)
Raymond Carroll - Texas A and M University (United States)
Irina Gaynanova - Texas A and M University (United States) [presenting]
Abstract: Canonical correlation analysis investigates linear relationships between two sets of variables, but often works poorly on modern data sets due to high-dimensionality and mixed data types (continuous/binary/zero-inflated). We propose a new approach for sparse canonical correlation analysis of mixed data types that does not require explicit parametric assumptions. The main contribution is the use of truncated latent Gaussian copula to model the data with excess zeroes, which allows us to derive a rank-based estimator of latent correlation matrix without the estimation of marginal transformation functions. The resulting semiparametric sparse canonical correlation analysis method works well in high-dimensional settings as demonstrated via numerical studies, and application to the analysis of association between gene expression and micro RNA data of breast cancer patients.