Title: Counting process based dimension reduction methods for censored outcomes
Authors: Ruoqing Zhu - University of Illinois at Urbana-Champaign (United States) [presenting]
Donglin Zeng - University of North Carolina at Chapel Hill (United States)
Qiang Sun - University of Toronto (United States)
Tao Wang - Shanghai Jiao Tong University (China)
Abstract: A class of dimension reduction methods for right censored survival data is proposed by using a counting process representation of the failure process. Semiparametric estimating equations are constructed to estimate the dimension reduction subspace for the failure time model. The proposed method addresses two fundamental limitations of existing approaches. First, using the counting process formulation, it does not require any estimation of the censoring distribution to compensate the bias in estimating the dimension reduction subspace. Second, the nonparametric part in the estimating equations is adaptive to the structural dimension, hence the approach circumvents the curse of dimensionality. Asymptotic normality is established for the obtained estimators. We further propose a computationally efficient approach that simplifies the estimation equation formulations and requires only a singular value decomposition to estimate the dimension reduction subspace. Numerical studies suggest that our new approaches exhibit significantly improved performance for estimating the true dimension reduction subspace. We further conduct a real data analysis on a skin cutaneous melanoma dataset from The Cancer Genome Atlas. The proposed method is implemented in the R package ``orthoDr''.