Title: On heritability estimation and genome-wide association study for Yorkshire pig family data
Authors: Woojoo Lee - Inha University (Korea, South)
Kyunghyun Nam - Department of Statistics, Inha University, Incheon, Republic of Korea. (Korea, South)
Donghyun Shin - Chonbuk National University (Korea, South)
Hyunman Sim - Department of Statistics, Inha University, Incheon, Republic of Korea (Korea, South) [presenting]
Abstract: Yorkshire pig family data collected in Korea contain various traits associated with meat, pedigree information and single nucleotide polymorphism (SNP) data. First, they were analyzed for heritability estimation and genome-wide association studies using genome-wide complex trait analysis (GCTA). However, since GCTA was originally developed for unrelated individuals, the validity of GCTA for our pig family data should be checked carefully. We compare (1) two heritability estimates and (2) two genome-wide association study results from pedigree information and SNP data, and study key causes to make differences between two approaches. Based on these, we discuss whether GCTA using SNP data provide reliable results for our Yorkshire pig family data.