Title: Quantification of multiple tumor clones using gene array data or sequencing data
Authors: Charles Kooperberg - Fred Hutchinson Cancer Research Center (United States) [presenting]
Abstract: It is not uncommon that tumor samples are in fact mixtures of several ``clones'' and possible also some normal cells. We describe a maximum likelihood based algorithm for determining what percentage of the tumor sample particular clones are from, as well as the copy number alterations of each of these clones, using nowadays quite economical gene array data or sequencing data. We illustrate our results on a cell-line data set of Barrett's esophagus, a pre-curser of esophageal cancer.