Title: Reliable detection of selection in cancer
Authors: Inigo Martincorena - Wellcome Trust Sanger Institute (United Kingdom) [presenting]
Abstract: Cancer is largely caused by somatic mutation and clonal selection. Yet, despite the central role of selection in cancer, tools to accurately quantify selection in cancer genomes are lacking. We will refine statistical methods from the field of molecular evolution to study selection in cancer. Applying these methods to 8,000 cancer exomes reveals that somatic evolution is characterised by a distinct and universal pattern of selection never seen in species evolution and clarifies the extent of positive and negative selection in cancer genomes.