Title: Gene hunting with knockoffs for hidden Markov Models
Authors: Matteo Sesia - Stanford University (United States) [presenting]
Chiara Sabatti - Stanford University (United States)
Emmanuel Candes - Stanford (United States)
Abstract: Modern scientific studies often require the identification of a subset of relevant explanatory variables, in the attempt to understand an interesting phenomenon. Several statistical methods have been developed to automate this task, but only recently has the framework of model-free knockoffs proposed a general solution that can perform variable selection under rigorous type-I error control, without relying on strong modeling assumptions. We extend the methodology of model-free knockoffs to a rich family of problems where the distribution of the covariates can be described by a hidden Markov model (HMM). We develop an exact and efficient algorithm to sample knockoff copies of an HMM. We then argue that combined with the knockoffs selective framework, they provide a natural and powerful tool for performing principled inference in genome-wide association studies with guaranteed false discovery rate control. Finally, we apply our methodology to several datasets aimed at studying Crohn's disease and several continuous phenotypes, e.g. levels of cholesterol.