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Title: Estimation and inference on high-dimensional individualized treatment rule in observational data Authors:  Yingqi Zhao - Fred Hutchinson Cancer Research Center (United States) [presenting]
Abstract: With the increasing adoption of electronic health records, there is an increasing interest in developing 25 individualized treatment rules, which recommend treatments according to patients characteristics, from large observational data. However, there is a lack of valid inference procedures for such rules developed from this type of data in the presence of high-dimensional covariates. We develop a penalized doubly robust method to estimate the optimal individualized treatment rule from high-dimensional data. We propose a split-and-pooled de-correlated score to construct hypothesis tests and confidence intervals. 30 Our proposal utilizes data splitting to conquer the slow convergence rate of nuisance parameter estimations, such as non-parametric methods for outcome regression or propensity models. We establish the limiting distributions of the split-and-pooled de-correlated score test and the corresponding one-step estimator in the high-dimensional setting. Simulation and real data analysis are conducted to demonstrate the superiority of the proposed method.