Title: Estimating recombination from population genetic data
Authors: Andreas Futschik - JKU Linz (Austria) [presenting]
Abstract: Recombination leads to the reshuffling of genetic material during meiosis. The population recombination rate is an important parameter which informs about the effect of recombination on populations. It is defined as four times the recombination rate per base pair and generation multiplied with the effective population size. Estimating the population recombination rate, as well as the identification of hotspots, is of considerable interest. Therefore several methods have been proposed for this purpose that are often computationally quite expensive. We discuss how existing estimates can be improved by optimizing the bias-variance trade-off. We also propose a new fast and accurate estimate that uses relevant summary statistics in a regression model.