Title: Genomic analysis of breast cancers and biomarkers of therapeutic responsiveness
Authors: Maggie Cheang - The Institute of Cancer Research (United Kingdom) [presenting]
Abstract: Various application of emerging technologies for biomarker research on FFPE materials will be discussed, in particular the integration of biomarker data from DNA, RNA, and proteomics-based assays for molecular classifications using breast cancer studies as the main examples. Various challenges and considerations taken in the study design and analytical methodologies when developing the PAM50 classifier will be shared. Several aspects to be considered will be discussed when planning a translational biomarker study with objectives to identify and develop genomics assays for sub-classification of tumours and to determine the sensitivity of each tumour type to therapeutic agents and targeted therapies.