Title: Preliminary application of multidimensional non-target analysis data by GCxGC/HRToFMS for environmental monitoring
Authors: Shunji Hashimoto - National Institute for Environmental Studies (Japan) [presenting]
Abstract: A non-target analytical method to measure as many chemical pollutants as possible to avoid missing of risk is being developed. One of the most important issues of non-target analysis is to detect anomaly condition of the environment. Stability and anomaly detection power of our method were statistically evaluated. Six samples collected from small river on six different days were used for examination. Each sample was divided into 5 sub-samples and those sub-samples were separately analyzed by the method. The data matrix size of one sub-sample measured by comprehensive two-dimensional gas-chromatography/ high-resolution time-of -flight mass spectrometry (GCxGC/HRToFMS) was 857(1st GC time) * 231(2nd GC time) * 16,800(mass) containing double-precision floating-point values (signal intensities). Although around several thousand components were detected from one sample, only 80 components in each sub-sample were tested. According to the results of Kruskal-Wallis test, it was possible to detect some difference inter samples even though within-group variation was relatively large. However, to enhance the sensitivity and reliability of difference detection inter samples, reproducibility and stability of non-target analytical method has to be improved.