Title: Nonparametric inference for right-censored data using smoothing splines
Authors: Meiling Hao - University of International Business and Economics (China) [presenting]
Yuanyuan Lin - The Chinese University of Hong Kong (Hong Kong)
Xingqiu Zhao - The Hong Kong Polytechnic University Shenzhen Research Institute (China)
Abstract: A penalized nonparametric maximum likelihood estimation of the log-hazard function for analyzing right-censored data is introduced. Smoothing splines are employed for a smooth estimation. Our main discovery is a functional Bahadur representation, which serves as a key tool for nonparametric inferences of an unknown function. The asymptotic properties of the resulting smoothing-spline estimator of the unknown log-hazard function are established under regularity conditions. Moreover, we provide a local confidence interval for this function, as well as local and global likelihood ratio tests. We also discuss the asymptotic efficiency of the estimator. The theoretical results are validated using extensive simulation studies. Lastly, we demonstrate the estimator by applying it to a real data set.