Title: Bayesian data integration in Cancer genomics
Authors: Francesco Stingo - University of Florence (Italy) [presenting]
Abstract: Identifying patient-specific prognostic biomarkers is of critical importance in developing personalized treatment for clinically and molecularly heterogeneous diseases such as cancer. We propose a novel regression framework, Bayesian hierarchical varying-sparsity regression models to select clinically relevant disease markers by integrating proteogenomic (proteomic+genomic) and clinical data. Our methods allow flexible modeling of protein-gene relationships as well as induces sparsity in both protein-gene and protein-survival relationships, to select genomically driven prognostic protein markers at the patient-level. We apply the proposed method to The Cancer Genome Atlas (TCGA) proteogenomic pan-cancer data and find several interesting prognostic proteins and pathways that are shared across multiple cancers and some that exclusively pertain to specific cancers.