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Title: The differences of restricted mean survival time curves estimated using pseudo-values Authors:  Federico Ambrogi - University of Milan (Italy) [presenting]
Simona Iacobelli - University of Rome Tor Vergata (Italy)
Per Kragh Andersen - University of Copenhagen (Denmark)
Abstract: Hazard ratios are ubiquitously used in time-to-event analysis to quantify treatment effects. Although hazard ratios are invaluable for hypothesis testing, other measures of association, both relative and absolute, may be used to fully elucidate study results. Restricted mean survival time differences between groups have been advocated as useful measures of association. Recent work focused on model-free estimates of the difference in restricted mean survival for all follow-up times instead of focusing on a single time horizon. The resulting curve can be used to quantify the association in time units with a simultaneous confidence band. A model-based alternative is proposed with estimation using pseudo-values easily implementable with available software. It is also possible to compute a confidence region for the curve. As a by-product, the ``time until treatment equipoise'' (TUTE) is also studied. Examples with crossing survival curves will be used to illustrate the different methods together with some simulations.