Title: Graph neural networks for multimodal single-cell data integration
Authors: Yuying Xie - Michigan State University (United States) [presenting]
Abstract: Recent advances in multimodal single-cell technologies have enabled simultaneous acquisitions of multiple omics data from the same cell, providing deeper insights into cellular states and dynamics. However, it is challenging to learn the joint representations from the multimodal data, model the relationship between modalities, and, more importantly, incorporate the vast amount of single-modality datasets into the downstream analyses. To address these challenges and correspondingly facilitate multimodal single-cell data analyses, three key tasks have been introduced: Modality prediction, Modality matching and joint embedding. We present a general Graph Neural Network framework scMoGNN to tackle these three tasks and show that scMoGNN demonstrates superior results in all three tasks compared with the state-of-the-art and conventional approaches. All implementations of our methods have been integrated into DANCE package.