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Title: Geospatial harmonization with multimodal geomarkers and R package developments Authors:  Erika Rasnick - Cincinnati Children's Hospital Medical Center (United States) [presenting]
Emrah Gecili - Cincinnati Children's Hospital Medical Center (United States)
Anushka Palipana - Cincinnati Children's Hospital Medical Center (United States)
Patrick Ryan - University of Cincinnati (United States)
Eleni-Rosalina Andrinopoulou - Erasmus Medical Center (Netherlands)
Pedro Miranda Afonso - Erasmus University Medical Center (Netherlands)
Ruth Keogh - London School of Hygiene and Tropical Medicine (United Kingdom)
John Clancy - Cystic Fibrosis Foundation (United States)
Rhonda Szczesniak - Cincinnati Children Hospital Medical Center (United States)
Cole Brokamp - University of Cincinnati (United States)
Abstract: It is known that environmental and place-based characteristics, termed geomarkers, play a role in the development and exacerbation of respiratory diseases such as cystic fibrosis (CF). However, geomarker data comes from many different sources, exists in diverse file formats, and is available at varying spatial and temporal extents and resolutions. We harmonized a set of geospatial variables, including air pollution exposure estimates from land use regression models, weather data, roadway proximity, neighborhood deprivation and crime, land use characteristics, and access to care. For each geomarker, we developed methods for estimating an individual's exposure based on their geocoded residential address, as well as postal ZIP code estimation for scenarios when full addresses are not available. We also created R packages that make geomarker data publicly available and easily accessible and make our geomarker workflows reproducible. The harmonized geomarker dataset and R packages were used for further analyses of CF and environmental and place-based exposures.