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Title: The value of the New Hampshire birth cohort: Impact of SARS Covid 2 on children's respiratory infections and symptoms Authors:  Susana Diaz Coto - Dartmouth College (United States) [presenting]
Janet Peacock - Dartmouth College (United States)
Vicki Sayarath - Geisel School of Medicine at Dartmouth Dartmouth College (United States)
Juliette Madan - Geisel School of Medicine at Dartmouth Dartmouth College (United States)
Margaret Karagas - Geisel School of Medicine at Dartmouth Dartmouth College (United States)
Abstract: Systematic data collection is one of the keys of scientific progress. Nowadays, these data frequently involve diverse sources and types of information, including microbiome, genetic, epigenetic and/or phenotypes, among others. The storage and harmonization of all these variables represent a non-trivial task, which deserves critical thinking and adequate systematic processes. The New Hampshire Birth Cohort Study (NHBCS) systematically collects a huge quantity of information related to mothers and newborns in New Hampshire (northeast of US) with the goal of examining associations between environmental exposures, maternal/child characteristics, and maternal/child outcomes. The NHBCS is part of the Environmental influences on Child Health Outcomes (ECHO) program that integrates 71 different but similar cohorts in US, and with more than 50,000 children enrolled is the largest US study of its kind. On the one hand, we present the technical structure and processes developed in the NHBCS to have a high-quality dataset; and, on the other hand, we illustrate the practical application for providing valuable knowledge on real-world issues. Particularly, we have used the NHBCS to study the impact of the virus SARS-Cov-2 on upper and lower tract respiratory infections and symptoms.