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B1118
Title: Maximum profile binomial likelihood estimation for the semiparametric Box--Cox power transformation model Authors:  Tao Yu - National University of Singapore (Singapore) [presenting]
Pengfei Li - University of Waterloo (Canada)
Baojiang Chen - University of Texas Health Science Center at Houston -- Austin Regional Campus (United States)
Jing Qin - National Institutes of Health (United States)
Abstract: The Box--Cox transformation model has been widely applied for many years. The parametric version of this model assumes that the random error follows a parametric distribution, say the normal distribution, and estimates the model parameters using the maximum likelihood method. The semiparametric version assumes that the distribution of the random error is completely unknown; existing methods either need strong assumptions, or are less effective when the distribution of the random error significantly deviates from the normal distribution. We adopt the semiparametric assumption and propose a maximum profile binomial likelihood method. We theoretically establish the joint distribution of the estimators of the model parameters. Through extensive numerical studies, we demonstrate that our method has an advantage over existing methods, especially when the distribution of the random error deviates from the normal distribution. Furthermore, we compare the performance of our method and existing methods on an HIV data set.